Updated May 15, 2024 by testing

Hello there!  ‘Isekai‘ is a subgenre of fantasy where characters get transported to a new world or a parallel universe, sounds fun? It is! Isekai anime is one of the best genres for me. Isekai has been top notch in the anime industry for a while.

It’s exciting, thrilling, adventurous and what not! I would love it if you give isekai animes a watch in your free period because personally, it freshens up my mood and soothes me. So welcome to iwatchitall, one of the best anime-based website for you in the whole internet!

Buckle up because I will give the best 16+ Isekai anime with female main leads. Now, have a comfortable seat because you will be reading my top picks for Isekai anime.

You can also check out: 33+ Manhwa (Webtoons) With Overpowered Female Characters

 

ISEKAI ANIME THAT HAS A FEMALE MAIN CHARACTER!

 

18. The Twelve Kingdoms 

Female MC	4/10
Isekai	5/10
Plot	4/10
Animation	5/10
Total	18/40

The twelve kingdoms also called “jūni kokki” means record of 12 countries. The female protagonist, “Youko Nakajima“, is a lovely, obedient, and kind kid. Unfortunately the students of her class take advantage of her sweetness, how sad is that.

Youko has no actual friends but one day, she met a man from another world in her classroom, the man claims that Youko is his master and she belongs to his kingdom. But the problems only began because the man was followed by a beast called “Youma“. 

I would prefer you to watch this adventurous anime as it will excite you to your heart’s content.

 

17. Vision Of Escaflowne 

Female MC	4/10
Isekai	5/10
Plot	6/10
Animation	5/10
Total	20/40

What to say about this marvelous Isekai. It consists of only 26 episodes, which will make you want more from it. The anime follows a teen girl named “Hitomi“, who is pulled from Earth to another planet called Gaea.

Throughout the whole anime, you will be experiencing thrilling fights and a lot of action, and yeah, Hitomi is cute but, Zerotwo is top tier for me, bleh! The 26 episodes show the overview of the war on the Zaibach empire. I will suggest for you to watch this thrill and action filled anime.

Who’s your waifu? Are they the best? Check out: 55+ Best Anime Waifus (RANKED)

 

16. Fushigi Yuugi

Female MC	5/10
Isekai	6/10
Plot	5/10
Animation	5/10
Total	21/40

Fushigi Yuugi, a proper Isekai-based anime will excite you from the very beginning as the 2 characters, “Miaka” and “Yui“, were swallowed by a book in the library. Wooh! Quite an appetite the book has. The anime is based on the mythological souls of China.

Miaka and Yui were good friends but after an incident, they became true rivals and things changed completely. This action-filled anime will keep your eyes on the screen the whole time. Definitely worth watching.

 

15. Sword Art Online Alternative: Gun Gale Online

Female MC	8/10
Isekai	7/10
Plot	7/10
Animation	6/10
Total	28/40

Karen Kohirumaki, called “Llenn” in the game, becomes one of the best players in no time in the game called Gun Gale Online. She is nicknamed the “pink devil” because of her fighting abilities and her pink costume. The character is very tall in real life so at first, Llenn played the game to only enjoy the short height of the in-game character, weird. But time after time, she started to enjoy the game and became a great player at last. No fans, the series doesn’t cast any SAO characters, instead it features a new set of characters. Add this jolly anime to your list as it will keep your mood up.

Related topic: Sword Art Online Watch Order (Complete Guide)

 

14. Ascendance of a Bookworm

Female MC	8/10
Isekai	8/10
Plot	8/10
Animation	5/10
Total	29/40

What to say about this anime? The lead character is so cute that I can barely  remove my eyes from her. College student “Urano Motosu” was a bookworm of another level who’s only motive was to be a librarian.

The anime consists of the main character being reincarnated to another world as the cute Urano faces a painful death during an earthquake. An excellent anime for the bookworms out there as the anime will be based on books throughout the whole session.

 

13. Bofuri: I Don’t Want To Get Hurt, So I’ll Max Out My Defenses 

Female MC	7/10
Isekai	8/10
Plot	7/10
Animation	8/10
Total	30/40

Bofuri is a comedy and action based anime. Why are the main leads getting cuter as we go down on the list? “Kaede Honjo” begins to play on NewWorld online as she was being convinced by her friend.

She, not wanting to get hurt, plays the game on full defense stats and each point she earns is put on her defense making the admins of the game stressed as she takes literally zero damage on hits. By repeating this throughout the whole game, it makes her one of the strongest players ever. This short 12 episode anime is worth your time.

Related topic to check out: 25+ Isekai Manhwa with OP MC (WEBTOONS)

 

12. Haruka: Beyond the Stream of Time

Female MC	9/10
Isekai	7/10
Plot	8/10
Animation	6/10
Total	30/40

Walking through the streets to her School, Motomiya Akane hears someone calling her from an old well. Motomiya then finds herself summoned into a world which resembles her hometown\. She is asked for a position that possesses the power of Gods. Throughout the whole anime, Akane is defending the world from the Oni clan.

Released in 2006 with just 2 episodes, is a must watch anime for the action lovers.

 

11. Kamigami No Asobi

Female MC	9/10
Isekai	8/10
Plot	6/10
Animation	8/10
Total	32/40

Yui, excellent with swords, is moved to the world of gods and goddesses to make them feel more pity for humans, a girl with a golden heart I’d say. Yui won the heart of the gods because of the loyalty and smartness she possessed.

She taught the Gods above and beyond for a better connection between them and the humans and wanted them to have a relationship between them as brothers and sisters. Why do they never make the anime girls ugly? They all are always topnotch. This soulful and heart touching anime will win your heart so you better watch it.

 

10. My Next Life As A Villainess

Female MC	10/10
Isekai	8/10
Plot	7/10
Animation	7/10
Total	32/40

There are many anime which don’t catch hype and attention but are masterpieces. Well, My Next Life As A Villainess is one of those anime. The 17 year old lead character named  “Catarina” reincarnated to a game as a villain after she had an accident when she was on her way to school.

All the routes in the game either lead to her death or her being exiled. How can I forget that Catarina is extra cute and kind, resulting in other characters falling in love with her. This Isekai filled with rom-com will keep you attentive throughout the whole series.

 

9. I’ve Been Killing Slimes For 300 Years And Maxed Out My level

Female MC	10/10
Isekai	9/10
Plot	7/10
Animation	6/10
Total	32/40

What? Such a long title for only 12 episodes in the anime? Poor Azusa Aizawa is an office worker who ends up dying from overworking and finds herself born in another world as an immortal and anti-aging witch. 

Now all she wants is to live without stress and hunt slimes for life, I already like her lifestyle. An anime worthy of your time.

Related topic: 32+ Best Manga Where The MC Is Reincarnated (Isekai’d)

 

8. The Saint’s Magic Power Is Omnipotent

Female MC	10/10
Isekai	9/10
Plot	6/10
Animation	7/10
Total	32/40

On her way home, the MC, ” Sei Takanashi ”, finds herself summoned in the dark aged land with a woman by her side to remove the dark magic from the region. Sei resulted in becoming a researcher at the institute of medicinal flora. She is kind and mature. She used her whole time working and learning new skills in magic potion making and magic. She is sincere, uh huh. 

She becomes powerful and proves herself to her colleagues. This anime gives you a little motivation. You can simp on Sei really hard as the character is extra cute. So that’s a strong point to watch this anime right?

Also Related topic to check: 46+ Isekai Anime with An Overpowered MC (Ranked)

 

7. Show By Rock

Female MC	9/10
Isekai	8/10
Plot	7/10
Animation	8/10
Total	32/40

In a world where music controls everything in the city. Cyan Hijirikawa decided to play one of her favorite games and eventually she got trapped inside it. Cyan is a talented girl with insane guitar skills, one her way in pursuit of becoming musical master in the city and to fight evil, Cyan is to defeat the evil with the power she resides in her, and she is so dumb to realize the power she has. Welcome to the world where music is everything. 

A wonderful jolly anime to raise up your mood with just 12 episodes in it.

 

6. No Game No Life

Female MC	7/10
Isekai	9/10
Plot	8/10
Animation	8/10
Total	32/40

The series starts as Sora and his sister Shiro dominate many games online using the username “blank“. They had a theory that life is a game. After an unfortunate event, they both are transported to Disboard. Sora and Shiro leave for the journey as Tet explains the rules of the world.

The siblings then encounter a foolish girl who is on the urge to regain her dad’s Empire. The siblings were inspired by the girl so they both decided to help the poor girl but with the vision of ruling the throne by themselves, evil isn’t it? A very fun and adventurous anime to watch and a very popular one too.

 

5. So I’m a spider, so what?

Female MC	10/10
Isekai	10/10
Plot	7/10
Animation	6/10
Total	33/40

There’s a lot of people who are afraid of spider, but would you still cower in fear if you see the lovable main character! Reincarnated as a weak monster inside the dungeon, our nameless main character must strive to survive as she fight different monster in order to live another day. Imagine waking up being a spider with vague memories about your post, it is overwhelming indeed. You’ll meet the main character with vague memory, but a jolly and hopeful personality!

 

4. Saga Of Tanya The Evil

Female MC	10/10
Isekai	10/10
Plot	5/10
Animation	8/10
Total	33/40

It is also known as “Youjo Senki”. A murdered salaryman who insulated and challenged  God just momenst before his death, is reincarnated as a 9 year old blonde girl named “Tanya Degurechaff” in a world of magical warfare. There she worked as a soldier. Despite her age and stature, Tanya really looks evil. 

Her combat and war abilities helped the mighty empire into becoming one of the strongest nations in history. The anime has a single season with 12 episodes in it which makes it really easy to watch. If you are ready to watch some action and hype, do give this anime a try.

 

3. Spirited Away

Female MC	10/10
Isekai	7/10
Plot	9/10
Animation	8/10
Total	34/40

A 10 year old “Chihiro“, was on her way to her new home with her parents, then a sudden urge of her father to take her to an amusement park turned out to be very traumatic for her, as her parents turned into pigs. Eh???? Chihiro faces many obstacles and struggles throughout the anime as she was pulled into a well to another world by demons.

Not to forget this anime movie holds an Oscar—the ONLY anime movie ever to achieve such a feat. That should be enough for you to go and watch this sensational movie.

2. Didn’t I Say to Make My Abilities Average in the Next Life?!

Female MC	9/10
Isekai	9/10
Plot	7/10
Animation	9/10
Total	34/40

This anime with a single season that was launched in 2019 is all about a girl who wished to be reincarnated in a magical world with a normal life but everything didn’t go as she planned. Misato Kurihara reborned as Adele Von Ascham with magical powers exceeding above average, opposite to what she wanted.

She left her home and joined a hunter school to hide her magical powers, but it was difficult for her to manage because of the crazy problems she was going to face. This 12 episode anime will keep you tight with featuring a cute MC too, that’s what I really like.

 

1. Inuyasha

Female MC	9/10
Isekai	10/10
Plot	10/10
Animation	9/10
Total	38/40

“Inuyasha” means half dog and half human. The character “Kagome Higurashi” is pulled into a well by the demons. Kagome was wanted in ancient Japan only for a jewel piece which she carries—a small piece that holds mighty, superpowers. It’s really scary for me.

Kagome then encounters a half demon boy named “Inuyasha” who mistakes Kagome as Kikyo because of the resemblance.

Eventually, the jewel was broken because of a battle and scattered all over. Inuyasha and Kagome are on a journey to collect all the broken parts of the jewel before it gets in the hand of someone evil.

Seriously, you can say it’s my favorite Isekai anime. The characters, the storyline, the adaptation, everything is perfectly aligned. Not to mention but the anime is a classic too.

 

Conclusion

That was it my friend! I hope you enjoyed being here and thought this was worth your time. Let me know in the comment section which list you want next. Also keep coming on iWatchitAll for more amazing content related to anime! BYE-BYE!
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